Ryan Witchell: The perfect storm: HIV and the rise of Chemsex

The last 20 years have seen huge strides in combating the disease. But changing attitudes and approaches to sex present new challenges.

A gamble that Osborne should not have taken

Goodbye, Austerity Chancellor. Hello, leadership contender. The Autumn Statement was framed to please Conservative backbenchers rather than crafted to balance the books.

David Gauke MP: We need reform as well as restraint – and the Chancellor’s statement will help to deliver both

In the last Parliament, we were able to reduce the cost of government substantially, with administrative budgets falling by 40 per cent. But we need to go further.

Daniel Hannan MEP: Why we must back Turkey against Putin

The idea that Turkey is somehow backing ISIS has become a popular meme, assiduously spread online by Russian agents provocateurs, and taken up by some in Western Europe,

Profile: France – and its future relationship with the EU

In the wake of the Paris bombings, the second of our profiles on European countries and institutions – and their role in Cameron’s EU renegotiation.

We ask our panel: What did you think of the Autumn Statement and Spending Review?

Including contributions from Andrew Boff, Natalie Elphicke, Mark Field MP, Alan Mak MP, Sean Worth and Zehra Zaidi.

Your at-a-glance guide to the Autumn Statement’s economic and fiscal forecasts

Our usual summary of the Office for Budget Responsibility’s supplementary data.

The main obstacle to a deal between the rival Leave campaigns is Arron Banks himself

The key Eurosceptic donors who will fund the anti-EU campaign do not feel they can work with him. Will he step aside to aid the cause?

Liam Fox MP: A debased currency. Eroded earnings. Devalued savings. Today, the Chancellor must tackle this other security threat.

This spending review brings the moment when the need to live within our means and the protection of sacred cows clash head-to-head.

From Reggie to Dessie: Letwin – fine, if you want the Times crossword completed in five minutes. But…

A pre-CSR session with the Chancellor at Dorneywood. Have the Chinese bugged Freya the Cut? DC One’s second-hand fittings. And: Boris Bearded.

Henry Hill: Tories put Labour under pressure in Holyrood polls

Also: Crabb concedes Wales should have more powers; Lords call to pause Scotland Bill; second SNP MP faces police investigation; First Minister of Ulster steps down; and more.

Tomorrow, Osborne must pass the surplus test

He has succeeded in boosting recovery, but failed to eliminate the deficit. Now he must prove his determination to fix that roof – whether the sun is shining or not.

Ruth Davidson MSP: The SNP’s independence plans have been exposed as delusional – when will they come clean?

Sturgeon and Swinney must stop relying on Salmond’s belligerent and baseless assertions.

John Baron MP: A successful Syrian intervention requires a grand strategy, and co-operation with Iran and Russia

We must be careful to learn the lessons of our past experiences in the region.

Jonathan Carr-West: Prime Minister Osborne, the curator of local economies, delivers in 2025

Localism must mean greater tax raising powers for councils.